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Weak/Intensive Metabolizers, CYP2D6 The formation on the Lively metabolite, M1, is mediated by CYP2D6, a polymorphic enzyme. Approximately seven% in the population has decreased action with the CYP2D6 isoenzyme of cytochrome P450 metabolizing enzyme procedure. These individuals are “weak metabolizers” of debrisoquine, dextromethorphan and tricy